Multimodality Investigation of High Density Lipoprotein Action in Atherosclerosis
نویسندگان
چکیده
T. Skajaa, D. P. Cormode, P. Jarzyna, A. Barazza, E. A. Fisher, R. E. Gordon, Z. A. Fayad, and W. J. Mulder Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY, United States, Faculty of Health Sciences, Aarhus, Denmark, School of Medicine, New York University, New York, NY, United States, Department of Pathology, Mount Sinai School of Medicine, New York, NY, United States
منابع مشابه
Relationship between High-Density Lipoprotein and C-reactive Protein in Patients with Atherosclerosis
Abstract Background and Objective: Atherosclerosis is an inflammatory disease mostly caused by oxidation of low density lipoproteins (LDLs) while High-density lipoproteins (HDLs) oppose atherosclerosis by inhibiting the oxidation of LDLs. Serum concentration of C- reactive protein (CRP) also increases as an acute phase protein in inflammatory conditions like atherosclerosis. We aimed to evalu...
متن کاملThe Effect of Eight Weeks of High-intensity Interval Training on Lipoprotein-associated Phospholipase A2 and Lipid Profile in a Male Rat Model of Type 2 Diabetes
Introduction: Type 2 diabetes (T2D) causes hyperglycemia, hyperinsulinemia, and dyslipidemia, which are all risk factors for atherosclerosis. Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been recognized as an indicator of atherosclerosis due to its role in vessel inflammation. This study aimed to investigate the effect of high-intensity interval training (HIIT) on serum levels of Lp-PL...
متن کاملResveratrol protects against diet-induced atherosclerosis by reducing low-density lipoprotein cholesterol and inhibiting inflammation in apolipoprotein E-deficient mice
Objective(s):Resveratrol (RES) is a polyphenol compound that has been shown a promising cardioprotective effect. However, some reports have yielded conflicting findings. Herein, we investigated the anti-atherosclerotic effects of RES in apolipoprotein E (apo E)-deficient mice on a high cholesterol diet. Materials and Methods: Firstly, atherosclerosis was induced by feeding a high cholesterol di...
متن کاملGlucose Influence on Copper Ion-Dependent Oxidation of Low Density Lipoprotein
Background: It is well established that oxidative modification of low density lipoprotein (LDL) plays a causal role in human atherogenesis and the risk of atherosclerosis is increased in patients with diabetes mellitus. We examined the in vitro effect of glucose on native and glycated LDL oxidation using copper ion dependent oxidation system. Methods: In this study, LDL was isolated from plasma...
متن کاملThe prevention and treatment effects of egg yolk high density lipoprotein on the formation of atherosclerosis plaque in rabbits
Objective(s): Atherosclerosis is the main leading cause of cardiovascular diseases. The purpose of this study was to assess the potential preventive effect of egg yolk HDL on the atherosclerosis plaque formation. Materials and Methods: Thirty rabbits were divided into five groups: A; normal diet, B; hyper-cholesterolemic diet, C; hypercholesterolemic + 400 mg/kg egg yolk HDL D; hypercholesterol...
متن کامل